Advil, Motrin (ibuprofen) dosing, indications, interactions, adverse effects, and more (2022)

  • acebutolol

    acebutolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of acebutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • aceclofenac

    aceclofenac and ibuprofen both increase anticoagulation. Use Caution/Monitor.aceclofenac and ibuprofen both increase serum potassium. Use Caution/Monitor.

  • acemetacin

    acemetacin and ibuprofen both increase anticoagulation. Use Caution/Monitor.acemetacin and ibuprofen both increase serum potassium. Use Caution/Monitor.

  • agrimony

    ibuprofen and agrimony both increase anticoagulation. Use Caution/Monitor.

  • albuterol

    ibuprofen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • alfalfa

    ibuprofen and alfalfa both increase anticoagulation. Use Caution/Monitor.

  • alfuzosin

    ibuprofen decreases effects of alfuzosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • aliskiren

    ibuprofen will decrease the level or effect of aliskiren by Other (see comment). Use Caution/Monitor. In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. Monitor renal function periodically.

  • alteplase

    ibuprofen and alteplase both increase anticoagulation. Use Caution/Monitor. Potential for increased risk of bleeding, caution is advised.

  • American ginseng

    ibuprofen and American ginseng both increase anticoagulation. Use Caution/Monitor.

  • amikacin

    ibuprofen increases levels of amikacin by decreasing renal clearance. Use Caution/Monitor. Interaction mainly occurs in preterm infants.

  • amiloride

    amiloride and ibuprofen both increase serum potassium. Modify Therapy/Monitor Closely.

  • antithrombin alfa

    antithrombin alfa and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

  • antithrombin III

    antithrombin III and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

  • arformoterol

    ibuprofen increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • argatroban

    argatroban and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

  • asenapine

    ibuprofen decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • aspirin

    aspirin and ibuprofen both increase anticoagulation. Use Caution/Monitor.aspirin and ibuprofen both increase serum potassium. Use Caution/Monitor.

  • aspirin rectal

    aspirin rectal and ibuprofen both increase anticoagulation. Use Caution/Monitor.aspirin rectal and ibuprofen both increase serum potassium. Use Caution/Monitor.

  • aspirin/citric acid/sodium bicarbonate

    aspirin/citric acid/sodium bicarbonate and ibuprofen both increase anticoagulation. Use Caution/Monitor.aspirin/citric acid/sodium bicarbonate and ibuprofen both increase serum potassium. Use Caution/Monitor.

  • atenolol

    atenolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of atenolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • azficel-T

    azficel-T, ibuprofen. Other (see comment). Use Caution/Monitor. Comment: Patients taking NSAIDS may experience increased bruising or bleeding at biopsy and/or injection sites. Concomitant use of NSAIDs is not recommended.

  • azilsartan

    ibuprofen, azilsartan.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.ibuprofen decreases effects of azilsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.

  • bemiparin

    bemiparin and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

  • benazepril

    benazepril, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • bendroflumethiazide

    ibuprofen increases and bendroflumethiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • betaxolol

    betaxolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of betaxolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • betrixaban

    ibuprofen, betrixaban.Either increases levels of the other by anticoagulation. Use Caution/Monitor.

  • bimatoprost

    bimatoprost, ibuprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

  • bisoprolol

    bisoprolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of bisoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • bivalirudin

    bivalirudin and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

  • budesonide

    ibuprofen, budesonide.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • bumetanide

    ibuprofen increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ibuprofen decreases effects of bumetanide by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • candesartan

    candesartan and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • captopril

    captopril, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • carbamazepine

    ibuprofen will increase the level or effect of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor plasma levels when used concomitantly

  • carbenoxolone

    ibuprofen increases and carbenoxolone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • carvedilol

    carvedilol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • celecoxib

    celecoxib and ibuprofen both increase anticoagulation. Use Caution/Monitor.celecoxib and ibuprofen both increase serum potassium. Use Caution/Monitor.

  • celiprolol

    celiprolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of celiprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • chlorothiazide

    ibuprofen increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • chlorpropamide

    ibuprofen increases effects of chlorpropamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

  • chlorthalidone

    ibuprofen increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • choline magnesium trisalicylate

    ibuprofen and choline magnesium trisalicylate both increase anticoagulation. Use Caution/Monitor.ibuprofen and choline magnesium trisalicylate both increase serum potassium. Use Caution/Monitor.

  • cinnamon

    ibuprofen and cinnamon both increase anticoagulation. Use Caution/Monitor.

  • ciprofloxacin

    ibuprofen, ciprofloxacin. Other (see comment). Modify Therapy/Monitor Closely. Comment: Mechanism: unknown. Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones.

  • citalopram

    citalopram, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. If possible, avoid concurrent use.

  • clomipramine

    clomipramine, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. Clomipramine inhib. serotonin uptake by platelets.

  • clopidogrel

    clopidogrel, ibuprofen.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Clopidogrel and NSAIDs both inhibit platelet aggregation.

  • cordyceps

    ibuprofen and cordyceps both increase anticoagulation. Use Caution/Monitor.

  • cortisone

    ibuprofen, cortisone.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • cyclopenthiazide

    ibuprofen increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • cyclosporine

    ibuprofen, cyclosporine.Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis, increasing the risk of nephrotoxicity.

  • dabigatran

    dabigatran and ibuprofen both increase anticoagulation. Use Caution/Monitor. Caution is advised, both drugs have the potential to cause bleeding. Concomitant use may increase risk of bleeding.

  • dalteparin

    dalteparin and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

  • deferasirox

    deferasirox, ibuprofen. Other (see comment). Use Caution/Monitor. Comment: Combination may increase GI bleeding, ulceration and irritation. Use with caution.

  • defibrotide

    defibrotide increases effects of ibuprofen by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Defibrotide may enhance effects of platelet inhibitors.

  • deflazacort

    ibuprofen, deflazacort.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • dexamethasone

    ibuprofen, dexamethasone.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • dichlorphenamide

    dichlorphenamide, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.

  • diclofenac

    diclofenac and ibuprofen both increase anticoagulation. Use Caution/Monitor.diclofenac and ibuprofen both increase serum potassium. Use Caution/Monitor.

  • diflunisal

    diflunisal and ibuprofen both increase anticoagulation. Use Caution/Monitor.diflunisal and ibuprofen both increase serum potassium. Use Caution/Monitor.

  • digoxin

    ibuprofen and digoxin both increase serum potassium. Use Caution/Monitor.

  • dobutamine

    ibuprofen increases and dobutamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dong quai

    ibuprofen and dong quai both increase anticoagulation. Use Caution/Monitor.

  • dopexamine

    ibuprofen increases and dopexamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • doxazosin

    ibuprofen decreases effects of doxazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • dronabinol

    ibuprofen will increase the level or effect of dronabinol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Dronabinol is a CYP2C9 substrate.

  • drospirenone

    drospirenone and ibuprofen both increase serum potassium. Modify Therapy/Monitor Closely.

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  • duloxetine

    duloxetine, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • edoxaban

    edoxaban, ibuprofen.Either increases toxicity of the other by anticoagulation. Modify Therapy/Monitor Closely. Both drugs have the potential to cause bleeding, monitor closely. Promptly evaluate any signs or symptoms of blood loss.

  • efavirenz

    efavirenz will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • eltrombopag

    eltrombopag increases levels of ibuprofen by decreasing metabolism. Use Caution/Monitor. UGT inhibition; significance of interaction unclear.

  • eluxadoline

    ibuprofen increases levels of eluxadoline by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. As a precautionary measure due to incomplete information on the metabolism of eluxadoline, use caution when coadministered with strong CYP2C9/10 inhibitors.

  • elvitegravir/cobicistat/emtricitabine/tenofovir DF

    elvitegravir/cobicistat/emtricitabine/tenofovir DF, ibuprofen.Either increases toxicity of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of emtricitabine and tenofovir with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.

  • emtricitabine

    emtricitabine, ibuprofen.Either increases levels of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of emtricitabine with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.

  • enalapril

    enalapril, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • enoxaparin

    enoxaparin and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

  • ephedrine

    ibuprofen increases and ephedrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • epinephrine

    ibuprofen increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • epinephrine racemic

    ibuprofen increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • epoprostenol

    ibuprofen and epoprostenol both increase anticoagulation. Use Caution/Monitor.

  • eprosartan

    eprosartan and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of eprosartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.eprosartan, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • escitalopram

    escitalopram, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • esmolol

    esmolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of esmolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • ethacrynic acid

    ibuprofen increases and ethacrynic acid decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • etodolac

    etodolac and ibuprofen both increase anticoagulation. Use Caution/Monitor.etodolac and ibuprofen both increase serum potassium. Use Caution/Monitor.

  • fennel

    ibuprofen and fennel both increase anticoagulation. Use Caution/Monitor.

  • fenoprofen

    fenoprofen and ibuprofen both increase anticoagulation. Use Caution/Monitor.fenoprofen and ibuprofen both increase serum potassium. Use Caution/Monitor.

  • feverfew

    ibuprofen and feverfew both increase anticoagulation. Use Caution/Monitor.

  • fish oil triglycerides

    fish oil triglycerides will increase the level or effect of ibuprofen by anticoagulation. Use Caution/Monitor. Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. Periodically monitor bleeding time in patients receiving fish oil triglycerides and concomitant antiplatelet agents or anticoagulants.

  • fludrocortisone

    ibuprofen, fludrocortisone.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • fluoxetine

    fluoxetine will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.fluoxetine, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • flurbiprofen

    flurbiprofen and ibuprofen both increase anticoagulation. Use Caution/Monitor.flurbiprofen and ibuprofen both increase serum potassium. Use Caution/Monitor.

  • fluvoxamine

    fluvoxamine, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding; SSRIs inhib. srotonin uptake by platelets.

  • fondaparinux

    fondaparinux and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

  • formoterol

    ibuprofen increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • forskolin

    ibuprofen and forskolin both increase anticoagulation. Use Caution/Monitor.

  • fosinopril

    fosinopril, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • furosemide

    ibuprofen increases and furosemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • garlic

    ibuprofen and garlic both increase anticoagulation. Use Caution/Monitor.

  • gemifloxacin

    gemifloxacin, ibuprofen. Other (see comment). Modify Therapy/Monitor Closely. Comment: Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones.

  • gentamicin

    ibuprofen increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ginger

    ibuprofen and ginger both increase anticoagulation. Use Caution/Monitor.

  • ginkgo biloba

    ibuprofen and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.

  • glimepiride

    ibuprofen increases effects of glimepiride by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

  • glipizide

    ibuprofen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

  • glyburide

    ibuprofen increases effects of glyburide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.ibuprofen increases levels of glyburide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Strong CYP2C9 inhibitors may decrease glyburide metabolism.

  • green tea

    green tea, ibuprofen. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

  • heparin

    heparin and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

  • horse chestnut seed

    ibuprofen and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.

  • hydralazine

    ibuprofen decreases effects of hydralazine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • hydrochlorothiazide

    ibuprofen increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • hydrocortisone

    ibuprofen, hydrocortisone.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • ibrutinib

    ibrutinib will increase the level or effect of ibuprofen by anticoagulation. Use Caution/Monitor. Ibrutinib may increase the risk of hemorrhage in patients receiving antiplatelet or anticoagulant therapies and monitor for signs of bleeding.

  • imatinib

    imatinib will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.imatinib, ibuprofen.Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely. Comment: Imatinib may cause thrombocytopenia; bleeding risk increased when imatinib is coadministered with anticoagulants, NSAIDs, platelet inhibitors, and thrombolytic agents.

  • indapamide

    ibuprofen increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • indomethacin

    ibuprofen and indomethacin both increase anticoagulation. Use Caution/Monitor.ibuprofen and indomethacin both increase serum potassium. Use Caution/Monitor.

  • irbesartan

    irbesartan and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of irbesartan by pharmacodynamic antagonism. Use Caution/Monitor. Antihypertensive effect of angiotensin receptor blockers may be attenuated by NSAIDs; monitor renal function and blood pressure periodically.irbesartan, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • isoproterenol

    ibuprofen increases and isoproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ketoprofen

    ibuprofen and ketoprofen both increase anticoagulation. Use Caution/Monitor.ibuprofen and ketoprofen both increase serum potassium. Use Caution/Monitor.

  • ketorolac

    ibuprofen and ketorolac both increase anticoagulation. Use Caution/Monitor.ibuprofen and ketorolac both increase serum potassium. Use Caution/Monitor.

  • ketorolac intranasal

    ibuprofen and ketorolac intranasal both increase anticoagulation. Use Caution/Monitor.ibuprofen and ketorolac intranasal both increase serum potassium. Use Caution/Monitor.

  • labetalol

    labetalol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of labetalol by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs diminish antihypertensive effects of beta-blockers.

  • lacosamide

    ibuprofen increases levels of lacosamide by affecting hepatic enzyme CYP2C9/10 metabolism. Modify Therapy/Monitor Closely. Consider decreasing lacosamide dose when coadministered with strong CYP2C9 inhibitors.

  • latanoprost

    latanoprost, ibuprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

  • latanoprostene bunod ophthalmic

    latanoprostene bunod ophthalmic, ibuprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

  • lesinurad

    ibuprofen will increase the level or effect of lesinurad by affecting hepatic enzyme CYP2C9/10 metabolism. Modify Therapy/Monitor Closely.

  • levalbuterol

    ibuprofen increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • levofloxacin

    levofloxacin, ibuprofen. Other (see comment). Modify Therapy/Monitor Closely. Comment: Risk of CNS stimulation/seizure. Mechanism: Displacement of GABA from receptors in brain.

  • levomilnacipran

    levomilnacipran, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. SNRIs may further impair platelet activity in patients taking antiplatelet or anticoagulant drugs.

  • lisinopril

    lisinopril, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • lithium

    ibuprofen increases levels of lithium by decreasing renal clearance. Use Caution/Monitor.

  • lornoxicam

    ibuprofen and lornoxicam both increase anticoagulation. Use Caution/Monitor.ibuprofen and lornoxicam both increase serum potassium. Use Caution/Monitor.

  • losartan

    losartan and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of losartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.losartan, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • lumacaftor/ivacaftor

    lumacaftor/ivacaftor will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Ibuprofen it a substrate of CYP2C9. Lumacaftor has the potential to induce CYP2C9 substrates.

  • meclofenamate

    meclofenamate and ibuprofen both increase anticoagulation. Use Caution/Monitor.meclofenamate and ibuprofen both increase serum potassium. Use Caution/Monitor.

  • mefenamic acid

    ibuprofen and mefenamic acid both increase anticoagulation. Use Caution/Monitor.ibuprofen and mefenamic acid both increase serum potassium. Use Caution/Monitor.

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  • melatonin

    melatonin increases effects of ibuprofen by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.

  • meloxicam

    ibuprofen and meloxicam both increase anticoagulation. Use Caution/Monitor.ibuprofen and meloxicam both increase serum potassium. Use Caution/Monitor.

  • mesalamine

    mesalamine, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive nephrotoxicity.

  • metaproterenol

    ibuprofen increases and metaproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • methyclothiazide

    ibuprofen increases and methyclothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

  • methylprednisolone

    ibuprofen, methylprednisolone.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • metolazone

    ibuprofen increases and metolazone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • metoprolol

    metoprolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of metoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • milnacipran

    milnacipran, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • mipomersen

    mipomersen, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs.

  • mistletoe

    ibuprofen increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • moexipril

    moexipril, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • moxifloxacin

    moxifloxacin, ibuprofen. Other (see comment). Modify Therapy/Monitor Closely. Comment: Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones.

  • moxisylyte

    ibuprofen decreases effects of moxisylyte by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • mycophenolate

    ibuprofen will increase the level or effect of mycophenolate by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.

  • nabumetone

    ibuprofen and nabumetone both increase anticoagulation. Use Caution/Monitor.ibuprofen and nabumetone both increase serum potassium. Use Caution/Monitor.

  • nadolol

    nadolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of nadolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • nebivolol

    nebivolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of nebivolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • nefazodone

    nefazodone, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • nettle

    ibuprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • norepinephrine

    ibuprofen increases and norepinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • olmesartan

    olmesartan and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of olmesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.olmesartan, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • ospemifene

    ibuprofen increases levels of ospemifene by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.ibuprofen, ospemifene.Either increases levels of the other by plasma protein binding competition. Modify Therapy/Monitor Closely.

  • panax ginseng

    ibuprofen and panax ginseng both increase anticoagulation. Use Caution/Monitor.

  • parecoxib

    ibuprofen and parecoxib both increase anticoagulation. Use Caution/Monitor.ibuprofen and parecoxib both increase serum potassium. Use Caution/Monitor.

  • paroxetine

    paroxetine, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • pau d'arco

    ibuprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.

  • pegaspargase

    pegaspargase increases effects of ibuprofen by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of bleeding events.

  • peginterferon alfa 2b

    peginterferon alfa 2b decreases levels of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. When patients are administered peginterferon alpha-2b with CYP2C9 substrates, the therapeutic effect of these drugs may be altered.

  • penbutolol

    penbutolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of penbutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • perindopril

    perindopril, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • phenindione

    phenindione and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

  • phenoxybenzamine

    ibuprofen decreases effects of phenoxybenzamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • phentolamine

    ibuprofen decreases effects of phentolamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • phytoestrogens

    ibuprofen and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

  • pindolol

    pindolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of pindolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • pirbuterol

    ibuprofen increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • piroxicam

    ibuprofen and piroxicam both increase anticoagulation. Use Caution/Monitor.ibuprofen and piroxicam both increase serum potassium. Use Caution/Monitor.

  • pivmecillinam

    pivmecillinam, ibuprofen.Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.pivmecillinam, ibuprofen.Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

  • potassium acid phosphate

    ibuprofen and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.

  • potassium chloride

    ibuprofen and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

  • potassium citrate

    ibuprofen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

  • potassium iodide

    potassium iodide and ibuprofen both increase serum potassium. Use Caution/Monitor.

  • pralatrexate

    ibuprofen increases levels of pralatrexate by decreasing renal clearance. Use Caution/Monitor. NSAIDs may delay pralatrexate clearance, increasing drug exposure. Adjust the pralatrexate dose as needed.

  • prasugrel

    ibuprofen, prasugrel.Either increases effects of the other by anticoagulation. Use Caution/Monitor. Chronic use of NSAIDs with prasugrel may increase bleeding risk.

  • prazosin

    ibuprofen decreases effects of prazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • prednisolone

    ibuprofen, prednisolone.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • prednisone

    ibuprofen, prednisone.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

  • probenecid

    ibuprofen will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.

  • propranolol

    propranolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of propranolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • protamine

    protamine and ibuprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

  • quinapril

    quinapril, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • ramipril

    ramipril, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • reishi

    ibuprofen and reishi both increase anticoagulation. Use Caution/Monitor.

  • reteplase

    ibuprofen and reteplase both increase anticoagulation. Use Caution/Monitor. Potential for increased risk of bleeding, caution is advised.

  • rivaroxaban

    rivaroxaban, ibuprofen. Other (see comment). Use Caution/Monitor. Comment: NSAIDs are known to increase bleeding. Bleeding risk may be increased when NSAIDs are used concomitantly with rivaroxaban. Monitor for signs/symptoms of blood loss.

  • rivastigmine

    rivastigmine increases toxicity of ibuprofen by pharmacodynamic synergism. Use Caution/Monitor. Monitor patients for symptoms of active or occult gastrointestinal bleeding.

  • sacubitril/valsartan

    sacubitril/valsartan and ibuprofen both increase serum potassium. Use Caution/Monitor.sacubitril/valsartan, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.ibuprofen decreases effects of sacubitril/valsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.

  • salicylates (non-asa)

    ibuprofen and salicylates (non-asa) both increase anticoagulation. Use Caution/Monitor.ibuprofen and salicylates (non-asa) both increase serum potassium. Use Caution/Monitor.

  • salmeterol

    ibuprofen increases and salmeterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • salsalate

    ibuprofen and salsalate both increase anticoagulation. Use Caution/Monitor.ibuprofen and salsalate both increase serum potassium. Use Caution/Monitor.

  • saw palmetto

    saw palmetto increases toxicity of ibuprofen by unspecified interaction mechanism. Use Caution/Monitor. May increase risk of bleeding.

  • sertraline

    sertraline, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • Siberian ginseng

    ibuprofen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

  • silodosin

    ibuprofen decreases effects of silodosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • sodium picosulfate/magnesium oxide/anhydrous citric acid

    ibuprofen, sodium picosulfate/magnesium oxide/anhydrous citric acid.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May be associated with fluid and electrolyte imbalances.

  • sodium sulfate/?magnesium sulfate/potassium chloride

    sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of ibuprofen by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.

  • sodium sulfate/potassium sulfate/magnesium sulfate

    sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of ibuprofen by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.

  • sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol

    ibuprofen, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol. Other (see comment). Use Caution/Monitor. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance.

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  • sotalol

    sotalol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of sotalol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • spironolactone

    spironolactone and ibuprofen both increase serum potassium. Modify Therapy/Monitor Closely.

  • succinylcholine

    ibuprofen and succinylcholine both increase serum potassium. Use Caution/Monitor.

  • sulfasalazine

    ibuprofen and sulfasalazine both increase anticoagulation. Use Caution/Monitor.ibuprofen and sulfasalazine both increase serum potassium. Use Caution/Monitor.

  • sulindac

    ibuprofen and sulindac both increase anticoagulation. Use Caution/Monitor.ibuprofen and sulindac both increase serum potassium. Use Caution/Monitor.

  • tafluprost

    tafluprost, ibuprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

  • telmisartan

    telmisartan and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of telmisartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.telmisartan, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • temocillin

    temocillin, ibuprofen.Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.temocillin, ibuprofen.Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

  • tenecteplase

    ibuprofen and tenecteplase both increase anticoagulation. Use Caution/Monitor. Potential for increased risk of bleeding, caution is advised.

  • tenofovir DF

    tenofovir DF, ibuprofen.Either increases levels of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of tenofovir DF with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.

  • terazosin

    ibuprofen decreases effects of terazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • terbinafine

    ibuprofen will increase the level or effect of terbinafine by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.

  • terbutaline

    ibuprofen increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ticagrelor

    ticagrelor, ibuprofen.Either increases effects of the other by anticoagulation. Use Caution/Monitor. Increased risk of bleeding with use of ticagrelor and chronic NSAID use. .

  • ticarcillin

    ticarcillin, ibuprofen.Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.ticarcillin, ibuprofen.Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

  • ticlopidine

    ticlopidine will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.ticlopidine increases toxicity of ibuprofen by anticoagulation. Use Caution/Monitor.

  • timolol

    timolol and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of timolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

  • tobramycin inhaled

    tobramycin inhaled and ibuprofen both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Avoid concurrent or sequential use to decrease risk for ototoxicity

  • tolazamide

    ibuprofen increases effects of tolazamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

  • tolbutamide

    ibuprofen increases effects of tolbutamide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

  • tolfenamic acid

    ibuprofen and tolfenamic acid both increase anticoagulation. Use Caution/Monitor.ibuprofen and tolfenamic acid both increase serum potassium. Use Caution/Monitor.

  • tolmetin

    ibuprofen and tolmetin both increase anticoagulation. Use Caution/Monitor.ibuprofen and tolmetin both increase serum potassium. Use Caution/Monitor.

  • tolvaptan

    ibuprofen and tolvaptan both increase serum potassium. Use Caution/Monitor.

  • torsemide

    ibuprofen increases and torsemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • trandolapril

    trandolapril, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • travoprost ophthalmic

    travoprost ophthalmic, ibuprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

  • trazodone

    trazodone, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • triamcinolone acetonide injectable suspension

    ibuprofen, triamcinolone acetonide injectable suspension.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Concomitant use of NSAIDS and corticosteroids increases the risk of gastrointestinal side effects. .

  • triamterene

    triamterene and ibuprofen both increase serum potassium. Modify Therapy/Monitor Closely.

  • valsartan

    valsartan and ibuprofen both increase serum potassium. Use Caution/Monitor.ibuprofen decreases effects of valsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.valsartan, ibuprofen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

  • venlafaxine

    venlafaxine, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

  • vitamin K1 (phytonadione)

    ibuprofen increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • voclosporin

    voclosporin, ibuprofen.Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity.

  • vorapaxar

    ibuprofen, vorapaxar.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive antiplatelet effect may occur.

  • vortioxetine

    ibuprofen, vortioxetine.Either increases effects of the other by anticoagulation. Use Caution/Monitor.

  • warfarin

    ibuprofen, warfarin.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Drugs with antiplatelet properties may increase anticoagulation effect of warfarin.

  • zanubrutinib

    ibuprofen, zanubrutinib.Either increases effects of the other by anticoagulation. Modify Therapy/Monitor Closely. Zanubrutinib-induced cytopenias increases risk of hemorrhage. Coadministration of zanubritinib with antiplatelets or anticoagulants may further increase this risk.

  • zotepine

    ibuprofen decreases effects of zotepine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

  • aceclofenac

    aceclofenac will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • acemetacin

    acemetacin will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • acyclovir

    ibuprofen will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • adefovir

    ibuprofen increases levels of adefovir by enhancing GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

  • alendronate

    ibuprofen, alendronate.Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of GI ulceration.

  • aminohippurate sodium

    ibuprofen will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • amiodarone

    amiodarone will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • amobarbital

    amobarbital will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • anamu

    ibuprofen and anamu both increase anticoagulation. Minor/Significance Unknown.

  • aspirin

    aspirin will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • aspirin rectal

    aspirin rectal will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • aspirin/citric acid/sodium bicarbonate

    aspirin/citric acid/sodium bicarbonate will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • balsalazide

    ibuprofen will increase the level or effect of balsalazide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • bendroflumethiazide

    bendroflumethiazide will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • bosentan

    bosentan will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • butabarbital

    butabarbital will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • butalbital

    butalbital will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • carbamazepine

    carbamazepine will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • cefadroxil

    cefadroxil will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • cefamandole

    cefamandole will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • cefdinir

    cefdinir will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • cefpirome

    cefpirome will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • ceftibuten

    ceftibuten will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • celecoxib

    celecoxib will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • cephalexin

    cephalexin will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • chlorothiazide

    chlorothiazide will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • chlorpropamide

    ibuprofen will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • chlorthalidone

    chlorthalidone will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • choline magnesium trisalicylate

    ibuprofen will increase the level or effect of choline magnesium trisalicylate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • cimetidine

    cimetidine will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

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  • creatine

    creatine, ibuprofen. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction) Combination may have additive nephrotoxic effects.

  • cyclopenthiazide

    cyclopenthiazide will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • danshen

    ibuprofen and danshen both increase anticoagulation. Minor/Significance Unknown.

  • devil's claw

    ibuprofen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

  • diclofenac

    diclofenac will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • diclofenac topical

    diclofenac topical, ibuprofen.Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Although low, there is systemic exposure to diclofenac topical; theoretically, concomitant administration with systemic NSAIDS or aspirin may result in increased NSAID adverse effects.

  • diflunisal

    diflunisal will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • digoxin

    ibuprofen increases levels of digoxin by decreasing renal clearance. Minor/Significance Unknown.

  • disulfiram

    disulfiram will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • eplerenone

    ibuprofen decreases effects of eplerenone by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

  • etodolac

    etodolac will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • etravirine

    etravirine will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • felbamate

    felbamate will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • fenoprofen

    fenoprofen will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • feverfew

    ibuprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

  • fluconazole

    fluconazole will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • flurbiprofen

    flurbiprofen will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • furosemide

    ibuprofen decreases effects of furosemide by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

  • ganciclovir

    ibuprofen will increase the level or effect of ganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • gentamicin

    ibuprofen increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • hydrochlorothiazide

    hydrochlorothiazide will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • imidapril

    ibuprofen decreases effects of imidapril by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

  • indapamide

    indapamide will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • indomethacin

    ibuprofen will increase the level or effect of indomethacin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • ketoconazole

    ketoconazole will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • ketoprofen

    ibuprofen will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • ketorolac

    ibuprofen will increase the level or effect of ketorolac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • ketorolac intranasal

    ibuprofen will increase the level or effect of ketorolac intranasal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • leflunomide

    leflunomide will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • levoketoconazole

    levoketoconazole will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • lornoxicam

    ibuprofen will increase the level or effect of lornoxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • meclofenamate

    meclofenamate will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • mefenamic acid

    ibuprofen will increase the level or effect of mefenamic acid by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • meloxicam

    ibuprofen will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • mesalamine

    ibuprofen will increase the level or effect of mesalamine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • methyclothiazide

    methyclothiazide will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • metolazone

    metolazone will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • metronidazole

    metronidazole will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • miconazole vaginal

    miconazole vaginal will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • nabumetone

    ibuprofen will increase the level or effect of nabumetone by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • nateglinide

    nateglinide will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • neomycin PO

    ibuprofen increases levels of neomycin PO by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • nilotinib

    nilotinib will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • noni juice

    ibuprofen and noni juice both increase serum potassium. Minor/Significance Unknown.

  • ofloxacin

    ofloxacin, ibuprofen. Other (see comment). Minor/Significance Unknown. Comment: Risk of CNS stimulation/seizure. Mechanism: Displacement of GABA from receptors in brain.

  • parecoxib

    ibuprofen will increase the level or effect of parecoxib by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • paromomycin

    ibuprofen increases levels of paromomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • pentobarbital

    pentobarbital will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • phenobarbital

    phenobarbital will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • piroxicam

    ibuprofen will increase the level or effect of piroxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • primidone

    primidone will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • rifampin

    rifampin will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • rifapentine

    rifapentine will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • rose hips

    rose hips will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • salicylates (non-asa)

    ibuprofen will increase the level or effect of salicylates (non-asa) by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • salsalate

    ibuprofen will increase the level or effect of salsalate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • secobarbital

    secobarbital will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • streptomycin

    ibuprofen increases levels of streptomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • sulfamethoxazole

    sulfamethoxazole will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • sulfasalazine

    ibuprofen will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • sulindac

    ibuprofen will increase the level or effect of sulindac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • tobramycin

    ibuprofen increases levels of tobramycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

  • tolfenamic acid

    ibuprofen will increase the level or effect of tolfenamic acid by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • tolmetin

    ibuprofen will increase the level or effect of tolmetin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • treosulfan

    treosulfan decreases effects of ibuprofen by Mechanism: unspecified interaction mechanism. Minor/Significance Unknown.

  • triamterene

    triamterene, ibuprofen. Other (see comment). Minor/Significance Unknown. Comment: Risk of acute renal failure. Mechanism: NSAIDs decrease prostaglandin synthesis, which normally protect against nephrotoxicity.ibuprofen increases toxicity of triamterene by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis, increasing the risk of nephrotoxicity.

  • valganciclovir

    ibuprofen will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • valproic acid

    valproic acid will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • vancomycin

    ibuprofen increases levels of vancomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in neonates.

    (Video) Ibuprofen (Brufen, Advil, Motrin, and Nurofen): Professional Medical Summary - In Depth

  • voriconazole

    voriconazole will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • willow bark

    ibuprofen will increase the level or effect of willow bark by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

  • zafirlukast

    zafirlukast will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

  • FAQs

    What is the indication for ibuprofen? ›

    IBUPROFEN INDICATIONS

    Like other OTC pain relievers, ibuprofen temporarily relieves minor aches and pains due to headache, backache, the common cold, minor pain of arthritis, toothache, menstrual cramps, and muscular aches, and temporarily reduces fever.

    What are the interactions of ibuprofen? ›

    Drug interactions

    Ibuprofen may slow the elimination of lithium or methotrexate, which could result in dangerous levels of these drugs. Naproxen interacts with alcohol, antidepressants, steroids, and blood thinners, so raising the risk of gastrointestinal bleeding and ulcers.

    What are the side effects of Advil? ›

    Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, loosening of skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red skin lesions, sore throat, sores, ulcers, white spots in mouth or on lips, or unusual tiredness or weakness .

    What drug classification is Motrin? ›

    Ibuprofen is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

    What is Advil used for? ›

    Advil Tablets. Advil has provided safe, effective pain relief for over 35+ years. So whether you have a headache, muscle aches, backaches, menstrual pain, minor arthritis and other joint pain, or aches and pains from the common cold, nothing's stronger when used as directed.

    How many mg is Advil? ›

    Advil is sold as tablets, caplets, or gel caplets with 200 mg of ibuprofen in each pill.

    What is ibuprofen used for and side effects? ›

    Ibuprofen is a painkiller available over the counter without a prescription. It's one of a group of painkillers called non-steroidal anti-inflammatory drugs (NSAIDs) and can be used to: ease mild to moderate pain – such as toothache, migraine and period pain.

    How does ibuprofen cause side effects? ›

    Ibuprofen changes your body's production of prostaglandins. This change can lead to an imbalance in your body fluid pressure, which can decrease your kidney function and increase your blood pressure. Symptoms of decreased kidney function include: increased blood pressure.

    What is the most common side effect associated with ibuprofen? ›

    Commonly reported side effects of ibuprofen include: hemorrhage, vomiting, anemia, decreased hemoglobin, eosinophilia, and hypertension. Other side effects include: upper gastrointestinal hemorrhage, upper gastrointestinal tract ulcer, dizziness, and dyspepsia.

    What are the effects of taking Advil everyday? ›

    While you can continue taking ibuprofen for a few days, it's not recommended that you take it daily to relieve pain unless your doctor has prescribed it. Medications like ibuprofen can irritate your stomach lining and cause problems ranging from mild nausea to ulcers.

    Who should not take ibuprofen? ›

    Who may not be able to take ibuprofen. Do not take ibuprofen by mouth or apply it to your skin if you: have ever had an allergic reaction or symptoms like wheezing, runny nose or skin reactions after taking aspirin, ibuprofen or other non-steroidal anti-inflammatory drugs (NSAIDs) such as naproxen. are pregnant.

    Does ibuprofen affect blood pressure? ›

    Ibuprofen (Advil, Motrin) can raise your blood pressure. But this change is usually small. If you have high blood pressure or heart problems, make sure to check with your healthcare provider before taking ibuprofen. Using ibuprofen regularly can cause potentially serious side effects, such as stomach ulcers.

    What is another name for ibuprofen? ›

    Some common brand names of ibuprofen include Advil and Motrin.

    What type of drug name is Advil? ›

    Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis), such as inflammation, swelling, stiffness, and joint pain.

    What is Motrin generic name? ›

    Ibuprofen (Advil, Motrin)

    Is Advil a drug or medicine? ›

    It is classified as a nonsteroidal anti-inflammatory drug (NSAID). Other members of this drug class include aspirin and naproxen (Aleve). As you may have guessed from the descriptions above, acetaminophen is best used for fever, aches and pains, but will not be very helpful if the pain is due to inflammation.

    Can you go to sleep after taking ibuprofen? ›

    Ibuprofen did not interfere with sleep in this study. Subjects treated with ibuprofen 400 mg TID (maxi- mum daily OTC dose) had a mean sleep efficiency of 88.6% on night 3.

    Is taking Advil healthy? ›

    While it's often effective for easing pain and inflammation and generally well-tolerated, Advil, and similar medications like Motrin, are associated with a number of possible side effects. Some of these are very serious, such as an increased risk of heart attack, stroke, and stomach bleeding.

    How many mg ibuprofen per Advil? ›

    nsaids-adult-dosing-chart.png
    Ibuprofen 200 mg For example MOTRIN® Regular Strength Advil® Regular Strength
    AMOUNT200 mg per pill
    DOSE & FREQUENCYMOTRIN® dosing: 1-2 pills every 4 to 6 hours Advil® dosing: 1 pill every 4 hours or 2 pills every 6 to 8 hours
    DAILY LIMIT*Do not take more than 6 pills in 24 hours
    8 more rows

    Is 2 Advil a day too much? ›

    Taking more Advil than intended can damage your stomach, intestines, or other organs. In some cases, an Advil overdose can be fatal. The recommended adult dosage is one or two 200 milligram (mg) tablets every 4 to 6 hours, not exceeding 800 mg at once or 3,200 mg per day.

    How many 200mg Advil can I take at once? ›

    The usual dose for adults is one or two 200mg tablets or capsules 3 times a day. In some cases, your doctor may prescribe a higher dose of up to 600mg to take 4 times a day if needed.

    What organ is affected by ibuprofen? ›

    Nonprescription pain relievers such as acetaminophen (Tylenol, others), aspirin, ibuprofen (Advil, Motrin IB, others) and naproxen (Aleve, others) can damage your liver, especially if taken frequently or combined with alcohol.

    Does ibuprofen affect urination? ›

    Bladder problems: This medication may cause bladder pain, painful or difficult urination, or increased frequency of urination.

    Does ibuprofen lower heart rate? ›

    The duration of the QRS complex wave (QRS duration) in ECG was prolonged. Although the heart rate was depressed by ibuprofen, the corrected QT interval duration (QTc) decreased.

    Does Advil cause kidney damage? ›

    Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis.

    How does ibuprofen affect the liver? ›

    The severity of the liver injury from ibuprofen ranges from asymptomatic elevations in serum aminotransferase levels to acute cholestatic hepatitis to acute liver failure and the need for transplantation. Several instances of chronic vanishing bile duct syndrome have been attributed to ibuprofen use.

    Can ibuprofen cause leg swelling? ›

    4) NSAIDs. Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Motrin, Advil) and naproxen (Aleve) are popular over-the-counter medications used for pain and inflammation. They are a well-known cause of swelling due to salt retention.

    Can ibuprofen cause muscle weakness? ›

    We conclude that a moderate dose of ibuprofen ingested after repeated resistance training sessions does not impair muscle hypertrophy or strength and does not affect ratings of muscle soreness.

    How much Advil is safe a day? ›

    Adults and teenagers—1200 milligrams (mg) up to 3200 mg per day divided into three or four equal doses. Children—Dose is based on body weight and must be determined by your doctor. The dose usually is 30 milligrams (mg) to 40 mg per kilogram (kg) of body weight per day, divided into three or four doses.

    Why is ibuprofen not recommended for elderly? ›

    Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of ibuprofen in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require adjustment of dosage in patients receiving ibuprofen .

    Is ibuprofen useful or harmful? ›

    Ibuprofen is generally safe to use for several years, but taking it for a long time or in high doses can increase your risk for stomach bleeding or ulcers. If you take this medicine for years, you may also be at an increased risk for heart attack or stroke.

    What happens if you take ibuprofen for no reason? ›

    Overuse of ibuprofen can seriously damage your digestive system, interfere with your hormones, and increase your risk of heart attacks and stroke. In some cases, ibuprofen overdose can be deadly.

    What can I take to sleep if I have high blood pressure? ›

    A guide to sleep aids: your options
    • Melatonin supplements. Melatonin is a sleep hormone that your body produces naturally, signaling the brain that it is time to go to bed. ...
    • Valerian root. ...
    • Magnesium. ...
    • Lavender plant. ...
    • Diphenhydramine: ...
    • Cyclizine:

    What can I take for arthritis pain if I have high blood pressure? ›

    The American Heart Association (AHA) has long recommended acetaminophen (Tylenol) as a safe alternative to nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve).

    What gets blood pressure down quickly? ›

    There's no quick and safe way to lower blood pressure outside of a medical setting. Lifestyle changes that incorporate exercise, diet, and stress-reducing techniques can naturally lower blood pressure over time.

    What is a stronger version of ibuprofen? ›

    by Drugs.com

    Meloxicam is considered a stronger medicine than ibuprofen. Meloxicam is only available on prescription and ibuprofen is available over the counter as well as on prescription. Meloxicam is a long-acting medicine that only needs to be given once a day.

    Does ibuprofen affect the kidneys? ›

    Acute kidney injury can happen with any NSAID, including ibuprofen. The risk for kidney damage is higher for adults over 60 and people who have chronic kidney disease (CKD). This serious side effect is seen most often within the first month of starting a regular NSAID regimen.

    What organ is Tylenol hard on? ›

    Tylenol is a common OTC pain reliever and fever reducer. But it does carry a risk of liver damage. Tylenol-related liver damage happens most when a person takes too much. When liver damage or failure happens, it's not always reversible and can be fatal.

    How can I protect my stomach from ibuprofen? ›

    Take NSAIDs at the end of a full meal or with an antacid

    Drugs that reduce stomach irritation include misoprostol (Cytotec), or a proton pump inhibitor such as omeprazole (Prilosec), esomeprazole (Nexium), pantoprazole (Protonix), lansoprazole (Prevacid), or rabeprazole (Aciphex).

    Why does ibuprofen help me sleep? ›

    Diphenhydramine is the active ingredient in Benadryl, an antihistamine taken for allergies. The ibuprofen will help easy any aches or pains. The diphenhydramine makes most people drowsy. That's why ibuprofen p.m. is probably helping you get to sleep.

    Does Motrin have caffeine? ›

    Motrin Migraine Pain contains no aspirin or caffeine, making it an attractive treatment option for migraine sufferers - many of whom combine medication with rest to alleviate the condition's debilitating effects.

    What's a substitute for Motrin? ›

    What Are Alternatives To Ibuprofen?
    • Acetaminophen (Tylenol) – should be taken at 500 mg, 1–2 tablets, every six hours as needed for pain. ...
    • Arnica – a homeopathic medication that can be taken orally or topically. ...
    • Bromelain – a pineapple extract and a natural anti-inflammatory.

    Does Motrin thin your blood? ›

    Advil is not a blood thinner. It is in a class of drugs called NSAIDS (nonsteroidal anti-inflammatory drugs). If you are taking a blood thinner, talk to your doctor before using Advil since it may impact how your blood clots in your body.

    What is the best use for ibuprofen? ›

    Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis), such as inflammation, swelling, stiffness, and joint pain.

    What is a contraindication for ibuprofen? ›

    Ibuprofen is contraindicated for use in patients with: known hypersensitivity or idiosyncratic reaction to ibuprofen (or any of the other ingredients in the product) known hypersensitivity to aspirin and other NSAIDs. asthma that is aspirin or NSAID sensitive.

    What is the main action of ibuprofen? ›

    The main mechanism of action of ibuprofen is the non-selective, reversible inhibition of the cyclooxygenase enzymes COX-1 and COX-2 (coded for by PTGS1 and PTGS2, respectively).

    What's the best painkiller for leg pain? ›

    Treatment may start with conservative therapies, such as over-the-counter aspirin, acetaminophen, or ibuprofen. These nonprescription medications can be effective for certain types of leg pain when taken according to instructions. You may also consider home care such as drinking plenty of water to reduce leg cramps.

    Is there something safer than ibuprofen? ›

    Acetaminophen is a safe alternative to NSAIDs for people who are allergic or hypersensitive to ibuprofen or other NSAIDs. In addition, certain supplements can help provide relief from inflammation and pain. Common alternatives to NSAIDs include arnica, curcumin, and bromelain.

    Does ibuprofen raise blood pressure? ›

    Ibuprofen (Advil, Motrin) can raise your blood pressure. But this change is usually small. If you have high blood pressure or heart problems, make sure to check with your healthcare provider before taking ibuprofen. Using ibuprofen regularly can cause potentially serious side effects, such as stomach ulcers.

    Are there any contraindications for Advil? ›

    Ibuprofen is contraindicated in patients with salicylate hypersensitivity or NSAID hypersensitivity who have experienced asthma, urticaria, or other allergic reactions (e.g., anaphylactic reactions and serious skin reactions) after taking ibuprofen, aspirin, or other NSAIDs.

    Who should not take Advil? ›

    Who may not be able to take ibuprofen. Do not take ibuprofen by mouth or apply it to your skin if you: have ever had an allergic reaction or symptoms like wheezing, runny nose or skin reactions after taking aspirin, ibuprofen or other non-steroidal anti-inflammatory drugs (NSAIDs) such as naproxen. are pregnant.

    What is ibuprofen made from? ›

    Ibuprofen was derived from propionic acid by the research arm of Boots Group during the 1960s. The name is derived from the 3 functional groups: isobutyl (ibu) propionic acid (pro) phenyl (fen). Its discovery was the result of research during the 1950s and 1960s to find a safer alternative to aspirin.

    Videos

    1. How and when to use Ibuprofen? (Brufen, Advil, Motrin, and Nurofen)
    (HOW TO MEDICATE)
    2. Ibuprofen |Advil / Motrin | Mechanism of Action |Dosage| Indications | Adverse Effect (English)
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    3. PEDIATRICIAN explains how to calculate tylenol/motrin/advil dosing for kids
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    4. Ibuprofen Side Effects - What You Need To Know
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    5. Ibuprofen and Naproxen (Advil/Motrin/Aleve)
    (Professor Dave Explains)
    6. Ibuprofen (Motrin, Advil) VS Acetaminophen (Tylenol) - Instances where Tylenol is preferred
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